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Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
BACKGROUND: Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75(NTR)) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in the CNS are not fully understood. RESULTS: Based on two rare single nucleotid...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743674/ https://www.ncbi.nlm.nih.gov/pubmed/19674479 http://dx.doi.org/10.1186/1756-6606-2-27 |