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Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter
HSCs are the founder cells of the adult hematopoietic system, and thus knowledge of the molecular program directing their generation during development is important for regenerative hematopoietic strategies. Runx1 is a pivotal transcription factor required for HSC generation in the vascular regions...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744041/ https://www.ncbi.nlm.nih.gov/pubmed/19129762 http://dx.doi.org/10.1038/nature07619 |