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TGF-β activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN
Akt kinase is activated by transforming growth factor-beta1 (TGF-β) in diabetic kidneys and plays important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells (MC)1–11. However, the mechanisms of Akt activation by TGF-β are not fully understood. Here we show that TGF-β ac...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744130/ https://www.ncbi.nlm.nih.gov/pubmed/19543271 http://dx.doi.org/10.1038/ncb1897 |