Presenilins are Essential for Regulating Neurotransmitter Release

Mutations in the presenilin genes are the major cause of familial Alzheimer's disease (AD). Loss of presenilin activity and/or accumulation of amyloid-β peptides have been proposed to mediate the pathogenesis of AD by impairing synaptic function1-5. However, the precise site and nature of the s...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Wu, Bei, Beglopoulos, Vassilios, Wines-Samuelson, Mary, Zhang, Dawei, Dragatsis, Ioannis, Südhof, Thomas C., Shen, Jie
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744588/
https://www.ncbi.nlm.nih.gov/pubmed/19641596
http://dx.doi.org/10.1038/nature08177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744588/
https://www.ncbi.nlm.nih.gov/pubmed/19641596
http://dx.doi.org/10.1038/nature08177

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