Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

BACKGROUND: Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic birth defect. Congenital heart defects (CHD) are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes rem...

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Detalles Bibliográficos
Autores principales: Delom, Frédéric, Burt, Emma, Hoischen, Alex, Veltman, Joris, Groet, Jürgen, Cotter, Finbarr E, Nizetic, Dean
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745369/
https://www.ncbi.nlm.nih.gov/pubmed/19715584
http://dx.doi.org/10.1186/1477-5956-7-31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745369/
https://www.ncbi.nlm.nih.gov/pubmed/19715584
http://dx.doi.org/10.1186/1477-5956-7-31

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