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Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix
BACKGROUND: Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic birth defect. Congenital heart defects (CHD) are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes rem...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745369/ https://www.ncbi.nlm.nih.gov/pubmed/19715584 http://dx.doi.org/10.1186/1477-5956-7-31 |