Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitations

BACKGROUND: Linking structural effects of mutations to functional outcomes is a major issue in structural bioinformatics, and many tools and studies have shown that specific structural properties such as stability and residue burial can be used to distinguish neutral variations and disease associate...

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Detalles Bibliográficos
Autores principales: Reumers, Joke, Schymkowitz, Joost, Rousseau, Fréderic
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745591/
https://www.ncbi.nlm.nih.gov/pubmed/19758473
http://dx.doi.org/10.1186/1471-2105-10-S8-S9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745591/
https://www.ncbi.nlm.nih.gov/pubmed/19758473
http://dx.doi.org/10.1186/1471-2105-10-S8-S9

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