Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at...

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Detalles Bibliográficos
Autores principales: Ghosh, Arun K., Gong, Gangli, Grum-Tokars, Valerie, Mulhearn, Debbie C., Baker, Susan C., Coughlin, Melissa, Prabhakar, Bellur S., Sleeman, Katrina, Johnson, Michael E., Mesecar, Andrew D.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745596/
https://www.ncbi.nlm.nih.gov/pubmed/18796354
http://dx.doi.org/10.1016/j.bmcl.2008.08.082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745596/
https://www.ncbi.nlm.nih.gov/pubmed/18796354
http://dx.doi.org/10.1016/j.bmcl.2008.08.082

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