Diversity of Chemical Mechanisms in Thioredoxin Catalysis Revealed by Single-Molecule Force Spectroscopy

Thioredoxins are oxido-reductase enzymes present in all organisms, catalyzing the reduction of disulfide bonds in proteins. By applying a calibrated force to a substrate disulfide, the chemical mechanisms of Trx catalysis can be examined in detail at the single molecule level. Here we use single mol...

Descripción completa

Detalles Bibliográficos
Autores principales: Perez-Jimenez, Raul, Li, Jingyuan, Kosuri, Pallav, Sanchez-Romero, Inmaculada, Wiita, Arun P., Rodriguez-Larrea, David, Chueca, Ana, Holmgren, Arne, Miranda-Vizuete, Antonio, Becker, Katja, Cho, Seung-Hyun, Beckwith, Jon, Gelhaye, Eric, Jacquot, Jean P., Gaucher, Eric, Sanchez-Ruiz, Jose M., Berne, Bruce J., Fernandez, Julio M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745927/
https://www.ncbi.nlm.nih.gov/pubmed/19597482
http://dx.doi.org/10.1038/nsmb.1627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745927/
https://www.ncbi.nlm.nih.gov/pubmed/19597482
http://dx.doi.org/10.1038/nsmb.1627

Ejemplares similares