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Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis

BACKGROUND: Cell surface heparan sulfate proteoglycans (HSPGs) act as co-receptors for multiple families of growth factors that regulate animal cell proliferation, differentiation and patterning. Elimination of heparan sulfate during brain development is known to produce severe structural abnormalit...

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Detalles Bibliográficos
Autores principales: Jen, Yi-Huei Linda, Musacchio, Michele, Lander, Arthur D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746204/
https://www.ncbi.nlm.nih.gov/pubmed/19732411
http://dx.doi.org/10.1186/1749-8104-4-33