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BtubA-BtubB Heterodimer Is an Essential Intermediate in Protofilament Assembly

BACKGROUND: BtubA and BtubB are two tubulin-like genes found in the bacterium Prosthecobacter. Our work and a previous crystal structure suggest that BtubB corresponds to α−tubulin and BtubA to β−tubulin. A 1∶1 mixture of the two proteins assembles into tubulin-like protofilaments, which further agg...

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Detalles Bibliográficos
Autores principales: Sontag, Christopher A., Sage, Harvey, Erickson, Harold P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746283/
https://www.ncbi.nlm.nih.gov/pubmed/19787042
http://dx.doi.org/10.1371/journal.pone.0007253