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A High-Throughput Approach for Identification of Novel General Anesthetics

Anesthetic development has been a largely empirical process. Recently, we described a GABAergic mimetic model system for anesthetic binding, based on apoferritin and an environment-sensitive fluorescent probe. Here, a competition assay based on 1-aminoanthracene and apoferritin has been taken to a h...

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Detalles Bibliográficos
Autores principales: Lea, Wendy A., Xi, Jin, Jadhav, Ajit, Lu, Louis, Austin, Christopher P., Simeonov, Anton, Eckenhoff, Roderic G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746312/
https://www.ncbi.nlm.nih.gov/pubmed/19777064
http://dx.doi.org/10.1371/journal.pone.0007150