Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug β-D-glucosyl-ifosfamide mustard

To study molecular aspects of cytotoxicity of the anticancer drug β-D-glucose-ifosfamide mustard we investigated the potential of the agent to induce apoptosis and DNA breakage. Since β-D-glucose-ifosfamide mustard generates DNA interstrand crosslinks, we used as an in vitro model system a pair of i...

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Detalles Bibliográficos
Autores principales: Becker, R, Ritter, A, Eichhorn, U, Lips, J, Bertram, B, Wiessler, M, Zdzienicka, M Z, Kaina, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746532/
https://www.ncbi.nlm.nih.gov/pubmed/11857024
http://dx.doi.org/10.1038/sj.bjc.6600027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746532/
https://www.ncbi.nlm.nih.gov/pubmed/11857024
http://dx.doi.org/10.1038/sj.bjc.6600027

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