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Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells

The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents. To test the hypothesis that extracellular matrix composition governs the penetration rate of macromolecules in tumour tissue, we measured the diffusion coefficient of nonspecific IgG in three rhabdomyosarcoma su...

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Detalles Bibliográficos
Autores principales: Davies, C de L, Berk, D A, Pluen, A, Jain, R K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746604/
https://www.ncbi.nlm.nih.gov/pubmed/12085216
http://dx.doi.org/10.1038/sj.bjc.6600270