Cargando…

Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells

BACKGROUND: Aberrant activation of Hedgehog (Hh) signaling pathway has been reported to be related to malignant biological behavior of pancreatic cancer but its mechanism is unclear yet. Since IGF pathway and Bcl-2 family are involved in proliferation and apoptosis of pancreatic cancer cells, we hyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Xuan-Fu, Guo, Chuan-Yong, Liu, Jun, Yang, Wen-Juan, Xia, Yu-Jing, Xu, Ling, Yu, Yong-Chun, Wang, Xing-Peng
Formato:	Texto
Lenguaje:	English
Publicado:	Medknow Publications 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746911/ https://www.ncbi.nlm.nih.gov/pubmed/19736394 http://dx.doi.org/10.4103/1477-3163.55429

Ejemplares similares

Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting
por: Huang, Xiu-yan, et al.
Publicado: (2016)

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer
por: He, ShanShan, et al.
Publicado: (2011)

Erratum to: Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting
por: Huang, Xiu-yan, et al.
Publicado: (2016)

IGFBP-4 regulates adult skeletal growth in a sex-specific manner
por: Maridas, David E, et al.
Publicado: (2017)

Distinct bulge stem cell populations maintain the pilosebaceous unit in a β-catenin-dependent manner
por: Han, Jimin, et al.
Publicado: (2022)

Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling
por: Zhang, Chuan, et al.
Publicado: (2016)

GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner
por: Xia, Zhizhou, et al.
Publicado: (2021)

Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer
por: Thomas, Divya, et al.
Publicado: (2020)

Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells
por: Chen, Zihang, et al.
Publicado: (2021)

Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells
por: Luciani, Dan S., et al.
Publicado: (2013)

The miR151 and miR5100 Transfected Bone Marrow Stromal Cells Increase Myoblast Fusion in IGFBP2 Dependent Manner
por: Mierzejewski, Bartosz, et al.
Publicado: (2022)

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
por: Wojciechowski, Sara, et al.
Publicado: (2007)

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6
por: Czerwinska, Patrycja, et al.
Publicado: (2020)

Kif3a Controls Murine Nephron Number Via GLI3 Repressor, Cell Survival, and Gene Expression in a Lineage-Specific Manner
por: Chi, Lijun, et al.
Publicado: (2013)

IGFBP1 Sustains Cell Survival during Spatially‐Confined Migration and Promotes Tumor Metastasis
por: Cai, Guoqing, et al.
Publicado: (2023)

IGFBP5 is Upregulated and Associated with Poor Prognosis in Colorectal Cancer
por: Deng, Yu, et al.
Publicado: (2022)

Comprehensive Analysis of Prognostic Value and Immune Infiltration of IGFBP Family Members in Glioblastoma
por: Zhong, Zhenglan, et al.
Publicado: (2022)

NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts
por: Ye, Ling, et al.
Publicado: (2018)

Mychonastes sp. 246 Suppresses Human Pancreatic Cancer Cell Growth via IGFBP3-PI3K-mTOR Signaling
por: Jang, Hyun-Jin, et al.
Publicado: (2023)

Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer
por: Kowolik, Claudia M., et al.
Publicado: (2019)

The Diagnostic Value of Serum IGFBP7 in Patients with Esophageal Squamous Cell Carcinoma
por: Huang, Xinyi, et al.
Publicado: (2019)

Regulation of IGFBP-2 expression during fasting
por: Kang, Hye Suk, et al.
Publicado: (2015)

MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma
por: Xu, Tianbo, et al.
Publicado: (2021)

Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk
por: Jin, Li, et al.
Publicado: (2020)

Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis
por: Lin, Zhongxiao, et al.
Publicado: (2016)

A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells
por: Falduto, Guido Hernan, et al.
Publicado: (2022)

Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6(+) ILC3s
por: Li, Yuling, et al.
Publicado: (2023)

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner()
por: Collette, Nicole M., et al.
Publicado: (2013)

Human Adipocytes Stimulate Invasion of Breast Cancer MCF-7 Cells by Secreting IGFBP-2
por: Wang, Chen, et al.
Publicado: (2015)

IGFBP2 Drives Regulatory T Cell Differentiation through STAT3/IDO Signaling Pathway in Pancreatic Cancer
por: Sun, Longhao, et al.
Publicado: (2022)

Caveolin-1 Is Up-Regulated by GLI1 and Contributes to GLI1-Driven EMT in Hepatocellular Carcinoma
por: Gai, Xiaohong, et al.
Publicado: (2014)

Silencing IGFBP-2 decreases pancreatic cancer metastasis and enhances chemotherapeutic sensitivity
por: Liu, Huan, et al.
Publicado: (2017)

The tripeptide N-Cbz-βGly-Gly-Gly-Obz
por: Nicholas, Sumesh
Publicado: (2015)

Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli
por: Han, Jin-bin, et al.
Publicado: (2013)

Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis
por: Guiot, J., et al.
Publicado: (2016)

Hypoxia Suppresses Spontaneous Mineralization and Osteogenic Differentiation of Mesenchymal Stem Cells via IGFBP3 Up-Regulation
por: Kim, Ji Hye, et al.
Publicado: (2016)

The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer
por: Jia, Yanfei, et al.
Publicado: (2018)

ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL
por: Li, Ji-Yu, et al.
Publicado: (2012)

Correction: Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6(+) ILC3s
por: Li, Yuling, et al.
Publicado: (2023)

GLI1 activation by non-classical pathway integrin α(v)β(3)/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis
por: Dong, Hui, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3gba7jl097mpmtcfnh6a5dco0d