Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7

Interferon regulatory factors (IRF)-3 and IRF-7 are master transcriptional factors that regulate type I IFN gene (IFN-α/β) induction and innate immune defenses after virus infection. Prior studies in mice with single deletions of the IRF-3 or IRF-7 genes showed increased vulnerability to West Nile v...

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Detalles Bibliográficos
Autores principales: Daffis, Stephane, Suthar, Mehul S., Szretter, Kristy J., Gale,, Michael, Diamond, Michael S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747008/
https://www.ncbi.nlm.nih.gov/pubmed/19798431
http://dx.doi.org/10.1371/journal.ppat.1000607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747008/
https://www.ncbi.nlm.nih.gov/pubmed/19798431
http://dx.doi.org/10.1371/journal.ppat.1000607

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