Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress

The aqueous extract of Anemarrhena asphodeloides (BN108) induces apoptosis in various cancer cell lines but is significantly less cytotoxic in non-transformed cells. Chemical fractionation of BN108 showed that its cytotoxicity is associated with timosaponins, steroidal saponins of coprostane type. T...

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Detalles Bibliográficos
Autores principales: King, Frank W., Fong, Sylvia, Griffin, Chandi, Shoemaker, Mark, Staub, Rick, Zhang, Yan-Ling, Cohen, Isaac, Shtivelman, Emma
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747272/
https://www.ncbi.nlm.nih.gov/pubmed/19789631
http://dx.doi.org/10.1371/journal.pone.0007283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747272/
https://www.ncbi.nlm.nih.gov/pubmed/19789631
http://dx.doi.org/10.1371/journal.pone.0007283

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