Clinical applications of functional MRI in epilepsy

The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation...

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Detalles Bibliográficos
Autores principales: Kesavadas, Chandrasekharan, Thomas, Bejoy
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747426/
https://www.ncbi.nlm.nih.gov/pubmed/19774159
http://dx.doi.org/10.4103/0971-3026.41829
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author Kesavadas, Chandrasekharan
Thomas, Bejoy
author_facet Kesavadas, Chandrasekharan
Thomas, Bejoy
author_sort Kesavadas, Chandrasekharan
collection PubMed
description The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed.
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spelling pubmed-27474262009-09-22 Clinical applications of functional MRI in epilepsy Kesavadas, Chandrasekharan Thomas, Bejoy Indian J Radiol Imaging Neuroradiology The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed. Medknow Publications 2008-08 /pmc/articles/PMC2747426/ /pubmed/19774159 http://dx.doi.org/10.4103/0971-3026.41829 Text en © Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neuroradiology
Kesavadas, Chandrasekharan
Thomas, Bejoy
Clinical applications of functional MRI in epilepsy
title Clinical applications of functional MRI in epilepsy
title_full Clinical applications of functional MRI in epilepsy
title_fullStr Clinical applications of functional MRI in epilepsy
title_full_unstemmed Clinical applications of functional MRI in epilepsy
title_short Clinical applications of functional MRI in epilepsy
title_sort clinical applications of functional mri in epilepsy
topic Neuroradiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747426/
https://www.ncbi.nlm.nih.gov/pubmed/19774159
http://dx.doi.org/10.4103/0971-3026.41829
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