Clinical applications of functional MRI in epilepsy
The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747426/ https://www.ncbi.nlm.nih.gov/pubmed/19774159 http://dx.doi.org/10.4103/0971-3026.41829 |
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author | Kesavadas, Chandrasekharan Thomas, Bejoy |
author_facet | Kesavadas, Chandrasekharan Thomas, Bejoy |
author_sort | Kesavadas, Chandrasekharan |
collection | PubMed |
description | The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed. |
format | Text |
id | pubmed-2747426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-27474262009-09-22 Clinical applications of functional MRI in epilepsy Kesavadas, Chandrasekharan Thomas, Bejoy Indian J Radiol Imaging Neuroradiology The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed. Medknow Publications 2008-08 /pmc/articles/PMC2747426/ /pubmed/19774159 http://dx.doi.org/10.4103/0971-3026.41829 Text en © Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neuroradiology Kesavadas, Chandrasekharan Thomas, Bejoy Clinical applications of functional MRI in epilepsy |
title | Clinical applications of functional MRI in epilepsy |
title_full | Clinical applications of functional MRI in epilepsy |
title_fullStr | Clinical applications of functional MRI in epilepsy |
title_full_unstemmed | Clinical applications of functional MRI in epilepsy |
title_short | Clinical applications of functional MRI in epilepsy |
title_sort | clinical applications of functional mri in epilepsy |
topic | Neuroradiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747426/ https://www.ncbi.nlm.nih.gov/pubmed/19774159 http://dx.doi.org/10.4103/0971-3026.41829 |
work_keys_str_mv | AT kesavadaschandrasekharan clinicalapplicationsoffunctionalmriinepilepsy AT thomasbejoy clinicalapplicationsoffunctionalmriinepilepsy |