Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis

Bone metastasis of breast cancer induces severe osteolysis with increased bone resorption. Osteoclast differentiation regulated by the receptor activator of NF-κB ligand (RANKL) in osteoblasts and matrix degradation induced by matrix metalloproteinases (MMPs) are thought to be involved in the proces...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohshiba, T, Miyaura, C, Inada, M, Ito, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747560/
https://www.ncbi.nlm.nih.gov/pubmed/12698202
http://dx.doi.org/10.1038/sj.bjc.6600858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747560/
https://www.ncbi.nlm.nih.gov/pubmed/12698202
http://dx.doi.org/10.1038/sj.bjc.6600858

Ejemplares similares