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Tracking the cell cycle origins for escape from topotecan action by breast cancer cells
The anticancer agent topotecan is considered to be S-phase specific. This implies that cancer cells that are not actively replicating DNA could resist the effects of the drug. The cycle specificity of topotecan action was investigated in MCF-7 cells, using time-lapse microscopy to link the initial c...
Autores principales: | Feeney, G P, Errington, R J, Wiltshire, M, Marquez, N, Chappell, S C, Smith, P J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747574/ https://www.ncbi.nlm.nih.gov/pubmed/12698201 http://dx.doi.org/10.1038/sj.bjc.6600889 |
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