Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of Escherichia coli MsbA, which were constructed in o...

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Detalles Bibliográficos
Autores principales: Ravna, Aina W, Sylte, Ingebrigt, Sager, Georg
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747915/
https://www.ncbi.nlm.nih.gov/pubmed/19732422
http://dx.doi.org/10.1186/1742-4682-6-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747915/
https://www.ncbi.nlm.nih.gov/pubmed/19732422
http://dx.doi.org/10.1186/1742-4682-6-20

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