Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

Toll-like receptors (TLRs) play a pivotal role in innate immunity and inflammation. Here we showed that genetic deficiency of Peli1, an E3 ubiquitin ligase, attenuates induction of proinflammatory cytokines by ligands of TLR3 and TLR4 and renders mice resistant to septic shock. Peli1 was required fo...

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Detalles Bibliográficos
Autores principales: Chang, Mikyoung, Jin, Wei, Sun, Shao-Cong
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748822/
https://www.ncbi.nlm.nih.gov/pubmed/19734906
http://dx.doi.org/10.1038/ni.1777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748822/
https://www.ncbi.nlm.nih.gov/pubmed/19734906
http://dx.doi.org/10.1038/ni.1777

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