Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain exhibits GTPase activity controlling LRRK2 kinase activity via an intramolecular process. We report the interaction of LRRK2 with the dishevelled family of phosphoproteins...

Descripción completa

Detalles Bibliográficos
Autores principales: Sancho, Rosa M., Law, Bernard M.H., Harvey, Kirsten
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748899/
https://www.ncbi.nlm.nih.gov/pubmed/19625296
http://dx.doi.org/10.1093/hmg/ddp337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748899/
https://www.ncbi.nlm.nih.gov/pubmed/19625296
http://dx.doi.org/10.1093/hmg/ddp337

Ejemplares similares