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Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

Mutations in PARK8, encoding LRRK2, are the most common known cause of Parkinson's disease. The LRRK2 Roc-COR tandem domain exhibits GTPase activity controlling LRRK2 kinase activity via an intramolecular process. We report the interaction of LRRK2 with the dishevelled family of phosphoproteins...

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Detalles Bibliográficos
Autores principales:	Sancho, Rosa M., Law, Bernard M.H., Harvey, Kirsten
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748899/ https://www.ncbi.nlm.nih.gov/pubmed/19625296 http://dx.doi.org/10.1093/hmg/ddp337

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