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Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations
BACKGROUND: The functional relevance of many of the recently detected JAK2 mutations, except V617F and exon 12 mutants, in patients with chronic myeloproliferative neoplasia (MPN) has been significantly overlooked. To explore atomic-level explanations of the possible mutational effects from those ov...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749040/ https://www.ncbi.nlm.nih.gov/pubmed/19744331 http://dx.doi.org/10.1186/1472-6807-9-58 |