Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

BACKGROUND: A deficiency in Perk (EIF2AK3) causes multiple neonatal defects in humans known as the Wolcott Rallison syndrome. Perk KO mice exhibit the same array of defects including permanent neonatal diabetes (PND). PND in mice was previously shown by us to be due to a decrease in beta cell prolif...

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Detalles Bibliográficos
Autores principales: Feng, Daorong, Wei, Jianwen, Gupta, Sounak, McGrath, Barbara C, Cavener, Douglas R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749809/
https://www.ncbi.nlm.nih.gov/pubmed/19732428
http://dx.doi.org/10.1186/1471-2121-10-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749809/
https://www.ncbi.nlm.nih.gov/pubmed/19732428
http://dx.doi.org/10.1186/1471-2121-10-61

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