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Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation
BACKGROUND: A deficiency in Perk (EIF2AK3) causes multiple neonatal defects in humans known as the Wolcott Rallison syndrome. Perk KO mice exhibit the same array of defects including permanent neonatal diabetes (PND). PND in mice was previously shown by us to be due to a decrease in beta cell prolif...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749809/ https://www.ncbi.nlm.nih.gov/pubmed/19732428 http://dx.doi.org/10.1186/1471-2121-10-61 |