The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition

INTRODUCTION: Notch is a family of transmembrane protein receptors whose activation requires proteolytic cleavage by γ-secretase. Since aberrant Notch signaling can induce mammary carcinomas in transgenic mice and high expression levels of Notch receptors and ligands correlates with overall poor cli...

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Detalles Bibliográficos
Autores principales: Han, Jianxun, Ma, Ivy, Hendzel, Michael J, Allalunis-Turner, Joan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750119/
https://www.ncbi.nlm.nih.gov/pubmed/19660128
http://dx.doi.org/10.1186/bcr2347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750119/
https://www.ncbi.nlm.nih.gov/pubmed/19660128
http://dx.doi.org/10.1186/bcr2347

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