Selective Inhibition of Protein Kinase C β(2) Attenuates Inducible Nitric Oxide Synthase–Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats

OBJECTIVE: Impaired cardiovascular function in diabetes is partially attributed to pathological overexpression of inducible nitric oxide synthase (iNOS) in cardiovascular tissues. We examined whether the hyperglycemia-induced increased expression of iNOS is protein kinase C-β(2) (PKCβ(2)) dependent...

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Detalles Bibliográficos
Autores principales: Nagareddy, Prabhakara Reddy, Soliman, Hesham, Lin, Guorong, Rajput, Padmesh S., Kumar, Ujendra, McNeill, John H., MacLeod, Kathleen M.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750218/
https://www.ncbi.nlm.nih.gov/pubmed/19587355
http://dx.doi.org/10.2337/db09-0432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750218/
https://www.ncbi.nlm.nih.gov/pubmed/19587355
http://dx.doi.org/10.2337/db09-0432

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