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Docetaxel: an alternative taxane in ovarian cancer
The taxanes paclitaxel and docetaxel are potent chemotherapeutic agents that block tubulin depolymerisation, leading to the inhibition of microtubule dynamics and cell cycle arrest. Although docetaxel and paclitaxel share a mutual tubulin binding site, mechanistic and pharmacological differences exi...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750619/ https://www.ncbi.nlm.nih.gov/pubmed/14661041 http://dx.doi.org/10.1038/sj.bjc.6601495 |