Inhibition of a Viral Enzyme by a Small Molecule Dimer Disruptor

Small molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi’s sarcoma-associated herpesvirus (KSHV) were identified by screening an α-helical mimetic library. Subsequently, a second generation of low micromolar inhibitors with improved potency and solubility was synthe...

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Detalles Bibliográficos
Autores principales: Shahian, Tina, Lee, Gregory M., Lazic, Ana, Arnold, Leggy A., Velusamy, Priya, Roels, Christina M., Kiplin Guy, R., Craik, Charles S.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752665/
https://www.ncbi.nlm.nih.gov/pubmed/19633659
http://dx.doi.org/10.1038/nchembio.192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752665/
https://www.ncbi.nlm.nih.gov/pubmed/19633659
http://dx.doi.org/10.1038/nchembio.192

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