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Inhibition of a Viral Enzyme by a Small Molecule Dimer Disruptor
Small molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi’s sarcoma-associated herpesvirus (KSHV) were identified by screening an α-helical mimetic library. Subsequently, a second generation of low micromolar inhibitors with improved potency and solubility was synthe...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752665/ https://www.ncbi.nlm.nih.gov/pubmed/19633659 http://dx.doi.org/10.1038/nchembio.192 |