Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential

To characterize the repair pathways of chromosome double-strand breaks (DSBs), one approach involves monitoring the repair of site-specific DSBs generated by rare-cutting endonucleases, such as I-SceI. Using this method, we first describe the roles of Ercc1, Msh2, Nbs1, Xrcc4, and Brca1 in a set of...

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Detalles Bibliográficos
Autores principales: Bennardo, Nicole, Gunn, Amanda, Cheng, Anita, Hasty, Paul, Stark, Jeremy M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752804/
https://www.ncbi.nlm.nih.gov/pubmed/19834534
http://dx.doi.org/10.1371/journal.pgen.1000683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752804/
https://www.ncbi.nlm.nih.gov/pubmed/19834534
http://dx.doi.org/10.1371/journal.pgen.1000683

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