Antimicrobial Activity of Human Prion Protein Is Mediated by Its N-Terminal Region

BACKGROUND: Cellular prion-related protein (PrP(c)) is a cell-surface protein that is ubiquitously expressed in the human body. The multifunctionality of PrP(c), and presence of an exposed cationic and heparin-binding N-terminus, a feature characterizing many antimicrobial peptides, made us hypotesi...

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Detalles Bibliográficos
Autores principales: Pasupuleti, Mukesh, Roupe, Markus, Rydengård, Victoria, Surewicz, Krystyna, Surewicz, Witold K., Chalupka, Anna, Malmsten, Martin, Sörensen, Ole E., Schmidtchen, Artur
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752989/
https://www.ncbi.nlm.nih.gov/pubmed/19809501
http://dx.doi.org/10.1371/journal.pone.0007358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752989/
https://www.ncbi.nlm.nih.gov/pubmed/19809501
http://dx.doi.org/10.1371/journal.pone.0007358

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