Tumor-Shed PGE(2) Impairs IL2Rγc-Signaling to Inhibit CD4(+) T Cell Survival: Regulation by Theaflavins

BACKGROUND: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of this immunomodulator in the survival of T helper cells remained unclear. Since...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Sreya, Bhattacharyya, Sankar, Saha, Baisakhi, Chakraborty, Juni, Mohanty, Suchismita, Sakib Hossain, Dewan Md., Banerjee, Shuvomoy, Das, Kaushik, Sa, Gaurisankar, Das, Tanya
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753647/
https://www.ncbi.nlm.nih.gov/pubmed/19812686
http://dx.doi.org/10.1371/journal.pone.0007382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753647/
https://www.ncbi.nlm.nih.gov/pubmed/19812686
http://dx.doi.org/10.1371/journal.pone.0007382

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