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Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERα)

Matrix metalloproteinases (MMPs) play a crucial role in migration of inflammatory cells into the central nervous system (CNS). Levels of MMP-9 are elevated in multiple sclerosis (MS) and predict the occurrence of new active lesions on magnetic resonance imaging (MRI). This translational study aims t...

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Detalles Bibliográficos
Autores principales: Gold, Stefan M, Sasidhar, Manda V, Morales, Laurie B, Du, Sienmi, Sicotte, Nancy L, Tiwari-Woodruff, Seema K., Voskuhl, Rhonda R
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753699/
https://www.ncbi.nlm.nih.gov/pubmed/19668239
http://dx.doi.org/10.1038/labinvest.2009.79