Dereplication and De Novo Sequencing of Nonribosomal Peptides

Nonribosomal peptides (NRPs) are of great pharmacological importance, but there is currently no technology for high-throughput NRP dereplication and sequencing. We employ multi-stage mass spectrometry followed by spectral alignment algorithms for sequencing of cyclic NRPs. We also present an algorit...

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Detalles Bibliográficos
Autores principales: Ng, Julio, Bandeira, Nuno, Liu, Wei-Ting, Ghassemian, Majid, Simmons, Thomas L., Gerwick, William, Linington, Roger, Dorrestein, Pieter, Pevzner, Pavel
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754211/
https://www.ncbi.nlm.nih.gov/pubmed/19597502
http://dx.doi.org/10.1038/nmeth.1350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754211/
https://www.ncbi.nlm.nih.gov/pubmed/19597502
http://dx.doi.org/10.1038/nmeth.1350

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