GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

Truncating GLI3 mutations in Pallister-Hall Syndrome with renal malformation suggests a requirement for Hedgehog signaling during renal development. HH-dependent signaling increases levels of GLI transcriptional activators and decreases processing of GLI3 to a shorter transcriptional repressor. Prev...

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Detalles Bibliográficos
Autores principales: Cain, Jason E., Islam, Epshita, Haxho, Fiona, Chen, Lin, Bridgewater, Darren, Nieuwenhuis, Erica, Hui, Chi-Chung, Rosenblum, Norman D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754339/
https://www.ncbi.nlm.nih.gov/pubmed/19809516
http://dx.doi.org/10.1371/journal.pone.0007313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754339/
https://www.ncbi.nlm.nih.gov/pubmed/19809516
http://dx.doi.org/10.1371/journal.pone.0007313

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