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GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

Truncating GLI3 mutations in Pallister-Hall Syndrome with renal malformation suggests a requirement for Hedgehog signaling during renal development. HH-dependent signaling increases levels of GLI transcriptional activators and decreases processing of GLI3 to a shorter transcriptional repressor. Prev...

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Detalles Bibliográficos
Autores principales:	Cain, Jason E., Islam, Epshita, Haxho, Fiona, Chen, Lin, Bridgewater, Darren, Nieuwenhuis, Erica, Hui, Chi-Chung, Rosenblum, Norman D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754339/ https://www.ncbi.nlm.nih.gov/pubmed/19809516 http://dx.doi.org/10.1371/journal.pone.0007313

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