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Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Substantially Stabilizes Proteins
The energetic contributions of hydrogen bonding to protein folding are still unclear, despite over 70 years of study. This is due partly to the difficulty of extracting thermodynamic information about specific interactions from protein mutagenesis data, and partly to the context dependence of hydrog...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754385/ https://www.ncbi.nlm.nih.gov/pubmed/19525973 http://dx.doi.org/10.1038/nsmb.1610 |