Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation

BACKGROUND: Bub1 is a component of the spindle assembly checkpoint, a surveillance mechanism that maintains chromosome stability during M-phase. Bub1 is essential during the early stages of embryogenesis, with homozygous BUB1-null mice dying shortly after day E3.5. Bub1 is also required later during...

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Detalles Bibliográficos
Autores principales: Tilston, Valerie, Taylor, Stephen S, Perera, David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754486/
https://www.ncbi.nlm.nih.gov/pubmed/19772675
http://dx.doi.org/10.1186/1756-0500-2-190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754486/
https://www.ncbi.nlm.nih.gov/pubmed/19772675
http://dx.doi.org/10.1186/1756-0500-2-190

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