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Inactivating the spindle checkpoint kinase Bub1 during embryonic development results in a global shutdown of proliferation
BACKGROUND: Bub1 is a component of the spindle assembly checkpoint, a surveillance mechanism that maintains chromosome stability during M-phase. Bub1 is essential during the early stages of embryogenesis, with homozygous BUB1-null mice dying shortly after day E3.5. Bub1 is also required later during...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754486/ https://www.ncbi.nlm.nih.gov/pubmed/19772675 http://dx.doi.org/10.1186/1756-0500-2-190 |