Epac2 induces synapse remodeling and depression and its disease-associated forms alter spine morphology

Dynamic remodeling of spiny synapses is crucial for cortical circuit development, refinement, and plasticity, while abnormal morphogenesis is associated with neuropsychiatric disorders. Here we show in cultured rat cortical neurons that activation of Epac2, a PKA-independent cAMP target and Rap guan...

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Detalles Bibliográficos
Autores principales: Woolfrey, Kevin M., Srivastava, Deepak P., Photowala, Huzefa, Yamashita, Megumi, Barbolina, Maria V., Cahill, Michael E., Xie, Zhong, Jones, Kelly A., Quilliam, Lawrence A., Prakriya, Murali, Penzes, Peter
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754861/
https://www.ncbi.nlm.nih.gov/pubmed/19734897
http://dx.doi.org/10.1038/nn.2386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754861/
https://www.ncbi.nlm.nih.gov/pubmed/19734897
http://dx.doi.org/10.1038/nn.2386

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