FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology

Fingolimod (FTY720) is the first of a novel class: sphingosine 1-phosphate (S1P) receptor modulator and is currently in phase 3 clinical trials for multiple sclerosis (MS). FTY720 was first synthesized in 1992 by chemical modification of an immunosuppressive natural product, ISP-I (myriocin). ISP-I...

Descripción completa

Detalles Bibliográficos
Autores principales: Adachi, Kunitomo, Chiba, Kenji
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754916/
https://www.ncbi.nlm.nih.gov/pubmed/19812733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754916/
https://www.ncbi.nlm.nih.gov/pubmed/19812733

Ejemplares similares