Chaperone Therapy for Neuronopathic Lysosomal Diseases: Competitive Inhibitors as Chemical Chaperones for Enhancement of Mutant Enzyme Activities

Chaperone therapy is a newly developed molecular approach to lysosomal diseases, a group of human genetic diseases causing severe brain damage. We found two valienamine derivatives, N-octyl-4-epi-β-valienamine (NOEV) and N-octyl-β-valienamine (NOV), as promising therapeutic agents for human β-galact...

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Detalles Bibliográficos
Autores principales: Suzuki, Yoshiyuki, Ogawa, Seiichiro, Sakakibara, Yasubumi
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754921/
https://www.ncbi.nlm.nih.gov/pubmed/19812739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754921/
https://www.ncbi.nlm.nih.gov/pubmed/19812739

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