Nicotine Binding to Brain Receptors Requires a Strong Cation-π Interaction

Nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ACh) receptors in the brain. The end result is over 4,000,000 smoking-related deaths annually worldwide and the largest source of preventable mortality in developed countries. Stress reduction, pleasure, improved cogn...

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Detalles Bibliográficos
Autores principales: Xiu, Xinan, Puskar, Nyssa L., Shanata, Jai A. P., Lester, Henry A., Dougherty, Dennis A.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755585/
https://www.ncbi.nlm.nih.gov/pubmed/19252481
http://dx.doi.org/10.1038/nature07768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755585/
https://www.ncbi.nlm.nih.gov/pubmed/19252481
http://dx.doi.org/10.1038/nature07768

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