Cargando…

The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity: INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS

It has been previously proposed that nitric oxide (NO) is the only biologically relevant nitrogen oxide capable of activating the enzyme soluble guanylate cyclase (sGC). However, recent reports implicate HNO as another possible activator of sGC. Herein, we examine the affect of HNO donors on the act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miller, Thomas W., Cherney, Melisa M., Lee, Andrea J., Francoleon, Nestor E., Farmer, Patrick J., King, S. Bruce, Hobbs, Adrian J., Miranda, Katrina M., Burstyn, Judith N., Fukuto, Jon M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2009
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755905/ https://www.ncbi.nlm.nih.gov/pubmed/19531488 http://dx.doi.org/10.1074/jbc.M109.014282

Ejemplares similares

Heme Regulatory Motifs in Heme Oxygenase-2 Form a Thiol/Disulfide Redox Switch That Responds to the Cellular Redox State
por: Yi, Li, et al.
Publicado: (2009)

Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis: IMPLICATIONS FOR TUBERCULOSIS
por: Mann, Francis M., et al.
Publicado: (2009)

Nitroxyl (HNO) Stimulates Soluble Guanylyl Cyclase to Suppress Cardiomyocyte Hypertrophy and Superoxide Generation
por: Lin, Eliane Q., et al.
Publicado: (2012)

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
por: Elliott, J. Michael, et al.
Publicado: (2009)

The Severe Acute Respiratory Syndrome (SARS) Coronavirus NTPase/Helicase Belongs to a Distinct Class of 5′ to 3′ Viral Helicases
por: Tanner, Julian A., et al.
Publicado: (2003)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
por: Baron, Rudi A., et al.
Publicado: (2009)

SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells
por: Huang, I-Chueh, et al.
Publicado: (2006)

Selective Inhibition of Carotenoid Cleavage Dioxygenases: PHENOTYPIC EFFECTS ON SHOOT BRANCHING
por: Sergeant, Martin J., et al.
Publicado: (2009)

Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)
por: Finn, Robert D., et al.
Publicado: (2008)

Time-dependent Autoinactivation of Phospho-Thr(286)-αCa(2+)/Calmodulin-dependent Protein Kinase II
por: Jama, Abdirahman M., et al.
Publicado: (2009)

Instability of Superoxide Dismutase 1 of Drosophila in Mutants Deficient for Its Cognate Copper Chaperone
por: Kirby, Kim, et al.
Publicado: (2008)

Porphyrins Promote the Association of GENOMES UNCOUPLED 4 and a Mg-chelatase Subunit with Chloroplast Membranes
por: Adhikari, Neil D., et al.
Publicado: (2009)

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms
por: Ehteshami, Maryam, et al.
Publicado: (2008)

Global Consequences of Activation Loop Phosphorylation on Protein Kinase A
por: Steichen, Jon M., et al.
Publicado: (2010)

Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2: BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1
por: Beretta, Matteo, et al.
Publicado: (2010)

Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome
por: Wygrecka, Malgorzata, et al.
Publicado: (2007)

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition
por: O'Brien, Theresa C., et al.
Publicado: (2008)

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin
por: Albet-Torres, Nuria, et al.
Publicado: (2009)

Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2
por: Wenzl, M. Verena, et al.
Publicado: (2009)

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
por: Lee, Cheng-Chung, et al.
Publicado: (2009)

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase
por: Briggs, Louise C., et al.
Publicado: (2008)

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase
por: Beran, Rudolf K. F., et al.
Publicado: (2008)

Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases
por: Beretta, Matteo, et al.
Publicado: (2008)

Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities
por: Fyfe, Paul K., et al.
Publicado: (2008)

Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin
por: Beretta, Matteo, et al.
Publicado: (2008)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations
por: Futai, Eugene, et al.
Publicado: (2009)

Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase
por: Irikura, Daisuke, et al.
Publicado: (2009)

The Significance of EXDD and RXKD Motif Conservation in Rel Proteins
por: Sajish, Mathew, et al.
Publicado: (2009)

Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue
por: Ren, Guoping, et al.
Publicado: (2009)

Arabidopsis GH3.12 (PBS3) Conjugates Amino Acids to 4-Substituted Benzoates and Is Inhibited by Salicylate
por: Okrent, Rachel A., et al.
Publicado: (2009)

Structure-based Mechanism of ADP-ribosylation by Sirtuins
por: Hawse, William F., et al.
Publicado: (2009)

SufA of the Opportunistic Pathogen Finegoldia magna Modulates Actions of the Antibacterial Chemokine MIG/CXCL9, Promoting Bacterial Survival during Epithelial Inflammation
por: Karlsson, Christofer, et al.
Publicado: (2009)

A Biosensor for Fluorescent Determination of ADP with High Time Resolution
por: Kunzelmann, Simone, et al.
Publicado: (2009)

Role of Bacillus subtilis BacB in the Synthesis of Bacilysin
por: Rajavel, Malligarjunan, et al.
Publicado: (2009)

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS
por: Torrie, Leah S., et al.
Publicado: (2009)

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase
por: Fan, Keqiang, et al.
Publicado: (2004)

The Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus Inhibits the Activity of Cyclin-Cyclin-dependent Kinase Complex and Blocks S Phase Progression in Mammalian Cells
por: Surjit, Milan, et al.
Publicado: (2006)

Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase
por: Chen, Hao, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_8ls72la5829edi9ti2akc2uls5