Structural Basis of the Catalytic Mechanism Operating in Open-Closed Conformers of Lipocalin Type Prostaglandin D Synthase

Lipocalin type prostaglandin D synthase (L-PGDS) is a multifunctional protein acting as a somnogen (PGD(2))-producing enzyme, an extracellular transporter of various lipophilic ligands, and an amyloid-β chaperone in human cerebrospinal fluid. In this study, we determined the crystal structures of tw...

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Detalles Bibliográficos
Autores principales: Kumasaka, Takashi, Aritake, Kosuke, Ago, Hideo, Irikura, Daisuke, Tsurumura, Toshiharu, Yamamoto, Masaki, Miyano, Masashi, Urade, Yoshihiro, Hayaishi, Osamu
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755957/
https://www.ncbi.nlm.nih.gov/pubmed/19546224
http://dx.doi.org/10.1074/jbc.M109.018341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755957/
https://www.ncbi.nlm.nih.gov/pubmed/19546224
http://dx.doi.org/10.1074/jbc.M109.018341

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