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Palmitoylation-dependent neurodevelopmental deficits in a mouse model of the 22q11 microdeletion
Individuals with 22q11.2 microdeletions have cognitive deficits and a high risk of developing schizophrenia. Here, we provide evidence that primary hippocampal neurons from a 22q11.2 deletion mouse model [Df(16)A(+/−)] have decreased density of dendritic spines and glutamatergic synapses, as well as...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756760/ https://www.ncbi.nlm.nih.gov/pubmed/18836441 http://dx.doi.org/10.1038/nn.2204 |