Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin

Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological. Binding to heparin increases the stability of FGF1 and is believed to be important in the formation of FGF1·fibroblast growth factor receptor...

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Detalles Bibliográficos
Autores principales: Zakrzewska, Malgorzata, Wiedlocha, Antoni, Szlachcic, Anna, Krowarsch, Daniel, Otlewski, Jacek, Olsnes, Sjur
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757240/
https://www.ncbi.nlm.nih.gov/pubmed/19574212
http://dx.doi.org/10.1074/jbc.M109.001289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757240/
https://www.ncbi.nlm.nih.gov/pubmed/19574212
http://dx.doi.org/10.1074/jbc.M109.001289

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